关键字：肾小管,微血管系统

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简介：Human kidney peritubular capillaries are particularly susceptible to injury, resulting in dysregulated angiogenesis, capillary rarefaction and regression, and progressive loss of kidney function. However, little is known about the structure and function of human kidney microvasculature. Here, we isolated, purified, and characterized human kidney peritubular microvascular endothelial cells (HKMECs) and reconstituted a three-dimensional human kidney microvasculature in a flow-directed microphysiologic system.In conclusion, this threedimensionalHKMEC-specificmicrophysiologic system recapitulates human kidneymicrovascular structure and function and shows phenotypic characteristics different from those of other microvascular endothelial cells.